2009
UC Development Aids in Longevity Research [10/1/09]
A mouse model developed by University of Cincinnati scientists has aided in the discovery of a protein signaling mechanism responsible for healthful longevity in female mice.
Drug Discovery Process More Accurate, Less Expensive Using Novel Application [9/17/09]
Cancer and cell biology experts at the University of Cincinnati (UC) have developed a new mass spectrometry-based tool they say provides more precise, cost-effective data collection for drug discovery efforts.
Enzyme Crucial to Insulin Resistance Found in Brain [9/14/09]
An enzyme known to cause insulin resistance in muscle is also located in the brain and has a similar function there, a research team that includes a University of Cincinnati scientist has found.
UC NEWS: Obesity Researcher Honored With Scientific Achievement Award [6/9/09]
Randy Seeley, PhD, University of Cincinnati professor of psychiatry and associate director of the Obesity Research Center, has been given the Outstanding Scientific Achievement Award by the American Diabetes Association (ADA).
UC NEWS: Fatty Foods—Not Empty Stomach—Fire Up Hunger Hormone [6/5/09]
New research led by the University of Cincinnati suggests that the hunger hormone ghrelin is activated by fats from the foods we eat—not those made in the body—in order to optimize nutrient metabolism and promote the storage of body fat.
UC NEWS: Cellular Discovery May Lead To Targeted Treatment for Rare Form of Anemia [3/15/09]
University of Cincinnati researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, their discoveries could result in drastic changes to current thinking about treatment for this disease and may lead to promising new drug therapies.
Bio-IT World: High Throughput Screening Retools for the Future [1/21/09]
HTS is evolving; users are learning how to apply HTS technology for optimal output, and the technologies HTS has spawned are extending downstream to lead optimization and compound profiling. Screener 6.0 is Genedata’s enterprise-wide data management platform for HTS and high-content screening (HCS). Genedata recently signed a collaboration with the Drug Discovery Center at the Genome Research Institute, University of Cincinnati, to fully integrate Screener into the center’s HTS workflow.
2008
New Scientist: Anti-Fat Pill Could Help Keep the Weight Off [12/8/08]A pill might replace that third helping of turkey at future Thanksgiving and Christmas dinners. A newly-discovered chemical found naturally in our body blocks hunger and weight gain.
NPR: Fatty Chemical Seen as Potential Appetite Curb [11/28/08]
Fatty foods prompt the body to produce a molecule called NAPE—short for N-Acylphosphatidylethanolamine.
Genedata, Drug Discovery Center Partner [11/5/08]
Genedata, a leading provider of in-silico solutions for pharmaceutical R&D and related life sciences, announced a High-Throughput Screening collaboration with the Drug Discovery Center at the University of Cincinnati's Genome Research Institute.
GRI Scientist in New Endowed Chair Position [9/29/08]
Randy Seeley, PhD, professor of psychiatry and associate director of UC's Obesity Research Center at the GRI, has been named to the Donald C. Harrison Endowed Chair in Medicine. This endowed chair position was established by Donald Harrison, MD, senior vice president and provost for health affairs from 1986 to 2002.
Slimming Effects of Fatty Diets? [8/12/08]
UC researchers, led by Matthias Tschoep, MD of UC's psychiatry department, along with colleagues from the Spanish National Cancer Research Center have found that higher levels of a specific protein called Sirt1 can actually reduce liver inflammation caused by high-fat diets and improve the liver’s tolerance to glucose.
GRI scientists and Ethicon engineers partner in $10.3 million agreement [3/26/08]
A three-year, $10.3 million commitment from Ethicon will support GRI scientists and Ethicon Endo-Surgery engineers as they work to find new solutions for treating obesity and related conditions, including diabetes. The GRI's Obesity Research Center, headed by Dr. Randy Seeley, will house the project.
Article featuring GRI scientist Deborah Clegg: How to Lose 10 Pounds [3/3/08]
GRI Scientist on Kidney Cancer Medical Advisory Board [2/5/08]
Dr. Maria Czyzyk-Krzeska, professor of molecular oncogenesis, is the newest member of the Kidney Cancer Association’s Medical Advisory Board. Dr. Czyzyk-Krzeska has funding from both the NIH and Department of Defense for research projects on kidney cancer.
Obesity Treatment Company Raises $16 Million [1/23/08]
New Approaches to Targeting and Killing Neuroblastoma Cells [1/1/08]
Dr. Sandra Nelson, of the GRI's Drug Discovery Center, is collaborating with investigators in the Cincinnati Children’s cancer program to screen for new anticancer drugs. The study is described in the Cincinnati Children's 2007 Annual Report.
2007
P&G Finds Big Success In Pharmaceutical Elusive [12/14/07]Genome Science Department is Now Molecular Oncogenesis [12/3/07]
The new name was approved by UC’s Board of Trustees at their Nov. 27, 2007, meeting and became effective Dec. 1, 2007. Jorge Moscat, PhD, professor and interim chair of molecular oncogenesis, says “This name change makes clear the connection between our department and the College of Medicine’s efforts to expand its cancer research initiatives."
Making the Industry-to-Academia Shift: Successful candidates tout their distinctive skill sets [11/15/07]
Ken Greis, PhD, Associate Professor and head of the Proteomics Laboratory at the GRI, is featured in an article on scientists who make the move from industry to academia.
Fat cell receptors may hold key to preventing obesity, diabetes [11/15/07]
GRI Researcher Receives Highest Honor Awarded to Young Scientists [11/5/07]
Jay Hove, PhD, has been named a winner of the prestigious 2006 Presidential Early Career Award for Scientists and Engineers (PECASE). PECASE is recognized as the highest award offered to young scientists by the United States government. Hove received the award during a morning reception at the White House Thursday, Nov. 1, 2007. He is the first scientist from UC to receive the honor.
Pharmasset Enters Antiviral Research Collaboration with the GRI [11/1/07]
Pharmasset and GRI's drug discovery professionals have entered into a collaboration to identify active and selective compounds against antiviral targets for hepatitis B virus, hepatitis C virus and human immunodeficiency virus.
University of Cincinnati Researchers Uncover Key to Battling Obesity [10/29/07]
Researchers from the University of Cincinnati, led by GRI scientist, David Hui, identified a cell receptor involved in fat transport. With the discovery of this receptor, scientists hope to eventually develop drugs to reduce the rate of fat transport to adipose (fat) tissue.
Brain clue could provide anti-obesity drugs [10/3/07]
Dr. Matthias Tschöp reported on experiments in rats showing that the hypothalamus helps determine how much food energy is stored, raising the possibility of a new kind of anti-obesity drug.
Scientists Discover how Brain Regulates Fat Metabolism [9/24/07]
Scientists led by GRI researcher Matthias Tschöp have discovered the brain region which, independent of the rate of food intake, controls whether excess energy is stored as fat or burned in our muscles.
Study: Menopause Can Make You Fat [8/22/07]
OBESITY’S HIDDEN CAUSES [8/22/07]
Dwindling estrogen in menopause could make women fat: study [8/22/07]
Revealing Estrogen's Secret Role In Obesity [8/21/07]
Estrogen Tells Brain Where Fat Goes [8/21/07]
Fat at Menopause Linked to Brain Estrogen Receptors [8/21/07]
GRI researcher, Deborah Clegg, reported to the American Chemical Society on a study showing a link between brain estrogen receptors and hormonal changes that increase visceral fat at menopause.
Researchers find link between molecule and obesity [6/20/07]
The Bsx of Obesity [6/19/07]
GRI scientists contributed to a recent report on a brain protein, Bsx, which controls our subconscious physical activity. Individual differences in Bsx levels could explain why some of us are innately more physically active than others and less prone to putting on body weight.
Fidgety Fish Could Hold Weight-Loss Clues [6/14/07]
GRI scientist Jay Hove, PhD, uses zebrafish as a model for obesity. By monitoring their movement and metabolic rates, he hopes to better understand how "fidgeting" affects caloric balance and which molecules may control that process.
The Science of Appetite [6/1/07]
GRI researcher Randy Seeley, PhD, Department of Psychiatry is featured in a Time Magazine article entitled, The Science of Appetite.
German Pharmacy Students Visit GRI [4/6/07]
Pharmacy students from the University of Munster spent a month in Cincinnati learning how German pharmacy training differs from ours. Jim Knittel, PhD (College of Pharmacy) hosted the students and gave them a project to work on in his lab at the GRI.
Ohio looks to the pharmaceutical industry for economic growth [2/28/07]
Omeris president, Tony Dennis, says from drug discovery through clinical trials expertise to marketing, Ohio boasts hundreds of companies that serve the world’s pharmaceutical leaders. He says the industry can boost local and state economies through its high-paying jobs. Cincinnati speakers in this radio report include executives from U-C’s Genome Research Institute, and Hill Top Research.
GRI Bolsters Research Team with New Recruits [1/3/07]
Jorge Moscat, PhD, and Maria Diaz-Meco, PhD, are two of the Genome Research Institute’s (GRI) newest recruits. The duo came to UC from the Spanish National Research Council—a major research organization similar to the National Institutes of Health.
2006
UC, Cincinnati Children's Partner to Enhance Drug Discovery [10/20/06]
CINCINNATI-The University of Cincinnati (UC) and Cincinnati Children's Hospital Center will partner with Evotec AG of Hamburg, Germany to enhance the potential for innovative drug discovery in southwest Ohio.
UC Scientiest Awarded Grant to Create '4-D' Camera [10/11/06]
University of Cincinnati (UC) physiologist Jay Hove, PhD, has been awarded a four-year, $1.53 million grant from the National Center for Research Resources of the National Institutes of Health to create a tool, a laser-illuminated "4-D camera," that he hopes will provide scientists with a better way to study cell and fluid movement in three dimensions plus-the fourth D-real time.
How To Soothe The Hungry Brain [10/3/06]
GRI Researcher, Angela Drew, Awarded Grant to Study Ovarian Cancer [7/17/06]
Study of Nutrients' Effects on Brain Provides Insight into Appetite Regulation [5/11/06]
Scientists from UC's Genome Research Institute demonstrated that the signaling pathway mTOR-activated by nutrient and hormonal signals-plays a role in the brain's ability to sense how much energy the body has available.
Public Event Explains Links Between Breast Cancer and Environment [5/2/06]
Study Links 'Hunger Hormone' to Memory and Learning [2/19/06]
2005
Chronic Stress Might Harm Women More Than it Does Men [11/15/05]Sweet Snacks Could be Best Medicine for Stress [11/15/05]
PROFILE: Researcher Spurred by Unconventional Ideas [9/26/05]
Researchers Identify New Target in Fight Against Obesity [9/19/05]
Research May Provide New Link Between Soft Drinks and Weight Gain [7/29/05]
UC Scientists Seek Answers to Health Problems in the Military [5/23/05]
UC Hosts Forum on Environmental Links to Breast Cancer [4/20/05]
Researchers Add New Tool to Tumor-Treatment Arsenal [3/24/05]
2004
Hunger Suppression [12/24/04]Ohio 'Lights' Nation's Leading Superscale Network [11/30/04]
Genome Center Woos Biotech Firm [11/8/04]
Scientist Whose Team Found Obesity Enzyme In Mice Coming to UC [8/13/04]
Lung Cancer Findings Cap Arduous Hunt [8/1/04]
No Anti-Fat Bullet [7/29/04]
UC Targets Potential Lung Cancer Gene for Treatment [7/28/04]
Lung Cancer Gene Region Identified [7/25/04]
Obesity 'Wonder Drug' Claims Lack Weight [7/20/04]
Labs Fail to Reproduce Protein's Appetite-Suppressing Effects [7/9/04]
UC: Obesity Treatment Premature [7/8/04]
Silver Bullet Obesity Pill Debunked by Later Studies [7/8/04]
Weight Problems May Not Be Your Fault [5/11/04]
A Bargain Basement Ferrari [4/28/04]
2003
GRI Partner Receives Third Frontier Funding [10/23/03]The Knowledge Industry [10/7/03]
GRI Grand Opening [10/6/03]
Genome Research [9/11/03]
2001
Millhorn Named Director of New UC Genome Research Institute [4/23/01]UC Board of Trustees Accepts Aventis Donation [1/23/01]