The Moscat and Diaz-Meco Lab

Jorge Moscat's Lab


Selected Publications:
Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J. Protein kinase C zeta isoform is critical for mitogenic signal transduction.Cell. 1993 Aug;74(3):555-63.

Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.Cell. 1996 Sep;86(5):777-86.

Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT. Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.Mol Cell Biol. 1998 May;18(5):3069-80.

Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J. Activation of IkappaB kinase beta by protein kinase C isoforms.Mol Cell Biol. 1999 Mar;19(3):2180-8.

Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.EMBO J. 1999 Jun;18(11):3044-53.

Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression.EMBO J. 1999 Nov;18(22):6362-9.

Sanz L, Diaz-Meco MT, Nakano H, Moscat J. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.EMBO J. 2000 Apr;19(7):1576-86.

Diaz-Meco MT, Moscat J. MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.Mol Cell Biol. 2001 Feb;21(4):1218-27.

Leitges M, Sanz L, Martin P, Duran A, Braun U, García JF, Camacho F, Diaz-Meco MT, Rennert PD, Moscat J. Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.Mol Cell. 2001 Oct;8(4):771-80.

Martin P, Duran A, Minguet S, Gaspar ML, Diaz-Meco MT, Rennert P, Leitges M, Moscat J. Role of zeta PKC in B-cell signaling and function.EMBO J. 2002 Aug;21(15):4049-57.

Avila A, Silverman N, Diaz-Meco MT, Moscat J. The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway.Mol Cell Biol. 2002 Dec;22(24):8787-95.

Duran A, Diaz-Meco MT, Moscat J. Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.EMBO J. 2003 Aug;22(15):3910-8.

Lafuente MJ, Martin P, Garcia-Cao I, Diaz-Meco MT, Serrano M, Moscat J. Regulation of mature T lymphocyte proliferation and differentiation by Par-4.EMBO J. 2003 Sep;22(18):4689-98.

Durán A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, Diaz-Meco MT. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.Dev Cell. 2004 Feb;6(2):303-9.

Sotillos S, Díaz-Meco MT, Caminero E, Moscat J, Campuzano S. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.J Cell Biol. 2004 Aug;166(4):549-57.

Durán A, Rodriguez A, Martin P, Serrano M, Flores JM, Leitges M, Diaz-Meco MT, Moscat J. Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.EMBO J. 2004 Nov;23(23):4595-605.

Martin P, Villares R, Rodriguez-Mascarenhas S, Zaballos A, Leitges M, Kovac J, Sizing I, Rennert P, Márquez G, Martínez-A C, Diaz-Meco MT, Moscat J. Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.Proc Natl Acad Sci U S A. 2005 Jul;102(28):9866-71.

Moscat J, Rennert P, Diaz-Meco MT. PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.Cell Death Differ. 2006 May;13(5):702-11.

Rodriguez A, Durán A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.Cell Metab. 2006 Mar;3(3):211-22.

Martin P, Diaz-Meco MT, Moscat J. The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.EMBO J. 2006 Aug;25(15):3524-33.

Moscat J, Diaz-Meco MT, Albert A, Campuzano S. Cell signaling and function organized by PB1 domain interactions.Mol Cell. 2006 Sep;23(5):631-40.

Moscat J, Diaz-Meco MT, Wooten MW. Signal integration and diversification through the p62 scaffold protein.Trends Biochem Sci. 2007 Feb;32(2):95-100.