FURTHER INFORMATION
William L. Seibel
Department of Molecular Oncogenesis
Genome Research Institute Room 147D
2180 E. Galbraith Rd.
Cincinnati, OH 45237
Phone: (513) 558-2706
FAX: (513) 558-5061
william.seibel@uc.edu
Email Bill
Department of Molecular Oncogenesis
Genome Research Institute Room 147D
2180 E. Galbraith Rd.
Cincinnati, OH 45237
Phone: (513) 558-2706
FAX: (513) 558-5061
william.seibel@uc.edu
Email Bill
Bill Seibel, PhD
Dr. Seibel serves as the Genome Research Institutes’ Director of Medicinal Chemistry and Compound Library Services: Dr. Seibel has 19 years of experience in the pharmaceutical industry and has led groups in the design and development of antibacterials, cardiovascular drugs, and anti-obesity agents. This work included optimization of known classes of drugs (e.g. quinolones, beta lactams, 2 agonists), and explorations into emerging targets in disease (e.g. melanocortin receptors, phosphatases, aminopeptidases), several of which have progressed into clinical trials. He has also led groups responsible for combinatorial chemistry, computational chemistry and structural biology, and currently oversees the operation of the UC/GRI Compound Library, a collection of over 250,000 drug-like compounds.
The UC/GRI Compound Library is comprised of over 250,000 compounds compiled to serve the broad screening needs of the academic research community. Compounds were carefully selected for adherence to drug-like properties and breadth of structural variety within this space. In addition, it has been augmented with libraries of compounds specifically targeting kinases, GPCRs, phosphatases and other prominent target classes of medicinal interest.
The compounds are housed in Haystack and Solar systems, two complimentary, automated storage and retrieval systems, allowing rapid delivery of compounds for biological screens in pure form or in 96/384 well plates. The system has a capacity for storage of over 200,000 neat compounds (Haystack) and over 1,500,000 compound in solutions (frozen DMSO).These materials are intended to be available to any academic investigators in order to assist them in identifying compounds of novel biological properties that might serve as useful research tools or as starting points for drug discovery. Please contact Dr. Seibel for discussions on how this library could be useful to your research programs.
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Education
University of Kansas B.S. Chemistry 1981
Harvard University Ph.D. Chemistry 1987
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Positions Held
University of Cincinnati
Director, Medicinal Chemistry and Compound Library Services [2006-Present]
Procter & Gamble Pharmaceuticals
Section Head, Structural Biology [2005-2006]
---Protein Production and Purification Group, Structural Biology Group (NMR and Crystallography), Modeling and Computational Chemistry Groups.
Section Head, Structure Based Drug Design [2004-2005]
---Structural Biology Group (Protein NMR and Crystallography), Modeling, Computational Chemistry Groups.
Section Head, Lead Discovery [2002-2004]
---Applied Parallel Synthesis Group, Modeling and Computational Chemistry.
Section Head, Combinatorial Chemistry [2001-2002]
---Parallel Synthesis Group and Compound Repository.
Section Head, Anti-Infectives Chemistry [1996-2002]
---Medicinal Chemistry group targeting novel antibacterials.
Senior Scientist [1991-1996]
---Design, synthesis and evaluation selective alpha-2 agonists.
Scientist [1987-1991]
---Design and synthesis of mechanism based compounds targeting anaerobic bacteria (anti-metabolites and anti-adherence), hypercholesterolemia, respiratory and tartar control.
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Publications
1. Conformationally defined adrenergic agents. 8. Synthesis of conformationally defined analogs of norfenfluramine. A highly stereospecific synthesis of amines from alcohols in the benzobicyclo[2.2.1]heptene system. Grunewald, Gary L.; Paradkar, Vidyadhar M.; Pazhenchevsky, Bharak; Pleiss, Michael A.; Sall, Daniel J.; Seibel, William L.; Reitz, Thomas J. Journal of Organic Chemistry 1983, 48(14), 2321-7.
2. First stereospecific synthesis of E-gamma-bisabolene. A method for the concurrent generation of a ring and a tetrasubstituted exocyclic double bond. Corey, E. J.; Seibel, William L. Tetrahedron Letters 1986, 27(8), 905-8.
3. A simple stereoselective synthesis of Z-gamma-bisabolene. Corey, E. J.; Seibel, William L. Tetrahedron Letters 1986, 27(8), 909-10.
4. Mechanism of the nitrous acid-induced dealkylation of trisubstituted (terminal isopropylidene) olefins to form acetylenes. Corey, E. J.; Seibel, William L.; Kappos, John C. Tetrahedron Letters 1987, 28(42), 4921-4.
5. Highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method for the analysis of dextromethorphan in human plasma. Eichhold, Thomas H.; Quijano, Mike; Seibel, William L.; Cruze, Charles A.; Dobson, Roy L. M.; R. Wehmeyer, Kenneth. Journal of Chromatography, B: Biomedical Sciences and Applications 1997, 698(1+2), 147-154.
6. A novel method for the efficient synthesis of 2-arylamino-2-imidazolines. Mundla, S. R.; Wilson, L. J.; Klopfenstein, S. R.; Seibel, W. L.; Nikolaides, N. N. Tetrahedron Letters 2000, 41(34), 6563-6566.
7. Applications of solid supported azide anion. A one-pot, two-step preparation of functionalized 1,2,3-triazoles. Blass, Benjamin E.; Coburn, Keith R.; Faulkner, Amy L.; Seibel, William L.; Srivastava, Anil Tetrahedron Letters 2003, 44(10), 2153-2155.
8. A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles. Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Seibel, William L. Tetrahedron Letters 2003, 44(14), 3009-3011.
9. Positional isomerization of quinine and quinidine via rhodium on alumina catalysis: practical one-step synthesis of 3,10-isoquinine and 3,10-isoquinidine. Portlock, David E.; Naskar, Dinabandhu; West, Laura; Seibel, William L.; Gu, Titan; Krauss, Howard J.; Peng, X. Sean; Dybas, Paul M.; Soyke, Edward G.; Ashton, Stephen B.; Burton, Jonathan. Tetrahedron Letters 2003, 44(28), 5365-5368.
10. Novel Petasis boronic acid-Mannich reactions with tertiary aromatic amines. Naskar, Dinabandhu; Roy, Amrita; Seibel, William L.; Portlock, David E. Tetrahedron Letters 2003, 44(31), 5819-5821.
11. Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. Hu, X Eric; Kim, Nick K; Gray, Jeffrey L; Almstead, Ji-In K; Seibel, William L; Ledoussal, Benoit. Journal of Medicinal Chemistry 2003, 46(17), 3655-61.
12. The synthesis of aza--lactams via tandem Petasis-Ugi multi-component condensation and 1,3-diisopropylcarbodiimide (DIC) condensation reaction. Naskar, Dinabandhu; Roy, Amrita; Seibel, William L.; West, Laura; Portlock, David E. Tetrahedron Letters 2003, 44(33), 6297-6300.
13. Novel Petasis boronic acid reactions with 1,3,5-tri-oxygenated benzenes. Naskar, Dinabandhu; Roy, Amrita; Seibel, William L. Tetrahedron Letters 2003, 44(49), 8861-8863.
14. Hydroxylamines and sulfinamide as amine components in the Petasis boronic acid-Mannich reaction: synthesis of N-hydroxy or alkoxy--aminocarboxylic acids and N-(tert-butyl sulfinyl)--amino carboxylic acids. Naskar, Dinabandhu; Roy, Amrita; Seibel, William L.; Portlock, David E. Tetrahedron Letters 2003, 44(49), 8865-8868.
15. Solution phase synthesis of imidazo[1,2-b]pyrazol-2-one, an interesting 5,5-fused heterocyclic ring system. Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Janusz, John J.; Ridgeway, James M.; Seibel, William L. Tetrahedron Letters 2004, 45(3), 619-621.
16. Solid-phase approach towards the synthesis of functionalized imidazo[1,2-b]pyrazol-2-ones. Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Janusz, John J.; Ridgeway, James M.; Seibel, William L. Tetrahedron Letters 2004, 45(6), 1275-1277.
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Patents
1. Halogenated aminohexanoates and aminobutyrates antimicrobial agents. Seibel, William L., Gardner, , Joseph H. The Procter & Gamble Company. Granted US Patent Number US 5096700. (3/17/1992).
2. 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists. Maurer, Peter Julian; Ares, Jeffrey Joseph; Seibel, William Lee; Walker, Daniel P. The Procter & Gamble Company. Granted US Patent Number US 5663189. (9/2/1997).
3. 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists. Maurer, Peter J.; Ares, Jeffrey J.; Seibel, William L.; Walker, Daniel P. ; Sheldon, Russell James; Henry, Raymond T. The Procter & Gamble Company. Granted US Patent Number US 5914342. (6/22/1999).
4. 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists. Maurer, Peter J.; Ares, Jeffrey J. ; Seibel, William L. ; Walker, Daniel P. ; Sheldon, Russell James; Henry, Raymond T. The Procter & Gamble Company. Granted US Patent Number US 5965595. (10/12/1999).
5. Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives. Godlewski, Michael Selden; Klopfenstein, Sean Rees; Mundla, Sreenivasa Reddy; Seibel, William Lee; Muth, Randy Stuart. The Procter & Gamble Company. Granted US Patent Number US 6066740. (5/23/2000).
6. 2-Imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists. Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee. The Procter & Gamble Company. Granted US Patent Number US 6110952. (8/29/2000).
7. 2-Imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists. Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee. The Procter & Gamble Company. Granted US Patent Number US 6162818. (12/19/2000).
8. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists. Cupps, Thomas Lee; Bogdan, Sophie Eva; Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee; Ares, Jeffrey Joseph. The Procter & Gamble Company. Granted US Patent Number US 6172095. (1/9/2001).
9. Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists. Cupps, Thomas Lee; Bogdan, Sophie Eva; Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee; Ares, Jeffrey Joseph. The Procter & Gamble Company. Granted US Patent Number US 6225331. (5/1/2001).
10. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists. Cupps, Thomas Lee; Bogdan, Sophie Eva; Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee; Ares, Jeffrey Joseph. The Procter & Gamble Co. Granted US Patent Number US 6306877. (10/23/2001).
11. Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists. Cupps, Thomas Lee; Bogdan, Sophie Eva; Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee; Ares, Jeffrey Joseph. The Procter & Gamble Company. Granted US Patent Number US 6391878. (5/21/2002).
12. 2-Imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists. Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee. The Procter & Gamble Company. Granted US Patent Number US 6395764. (5/28/2002).
13. Guanidinylamino heterocycle compounds useful as .alpha.-2 adrenoceptor agonists. Cupps, Thomas Lee; Bogdan, Sophie Eva; Henry, Raymond Todd; Sheldon, Russell James; Seibel, William Lee; Ares, Jeffrey Joseph. The Procter & Gamble Co. Granted US Patent Number US 6436978. (8/20/2002).
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Presentations (National)
1. The Synthesis of Indan-based imidazolidine derivatives. M.L. Baker, W.L. Seibel, J.P. Lillibridge, and K. Rasmussen-Ortega, 208th National ACS Meeting, Washington DC, OH, USA. August 21-26, 1994
2. 3-Dithiocarbamoylcarbacephalosporins possessing in vitro activity against resistant gram-positive bacteria. White, R.E.; Chen, Z.; Stanton, K.J.; Jackson, C.M.; Laughlin, S.K.; Lu, W.P.; Mikesell, C.B.; Koenigs, P.M.; Wallace, C.D.; Zoutendam, P.H.; Canty, J.F.; Meiling, G.E.; Barnett, B.L. Kraft, W.G.; Seibel, W.L.; Demuth Jr., T.P. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, ON, Canada, Sept. 17-20, 2000.
3. Synthesis and biological properties of biarylamide antibacterial agents. Hershberger, P.M.; Shrum, G.P.; Wilson, L.J.; Sunder, S.; Seibel, W.L.; Parker, C.N.; Morris, T.W.; Reneck, P.J.; Davis, M.C.; Bierman, J.C.; Emig, J.E.; Zoutendam, P.H.; Gavin, M.; Burt, T.M.; Canty, J.F.; Stanton, D.T., Madhav, P.J. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, Sept. 26-29, 1999.
4. Discovery of 3-Dithiocarbamoylcephalosporins highly active in vitro activity against resistant gram-positive bacteria. Chen, Z.; White, R.E.; Laughlin, S.K.; Stanton, K.J.; Koenigs, McKeever, H.D.; Wallace, C.D.; C.M.; Lu, W.P.; Mikesell, C.B.; Zoutendam, P.H.; Canty, J.F.; Meiling, G.E.; Barnett, B.L. Kraft, W.G.; Seibel, W.L.; Demuth Jr., T.P. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, ON, Canada, Sept. 17-20, 2000.
5. Design and synthesis of bestatin derivatives as potential inhibitors of bacterial methionine aminopeptidase. Soper, Shari J.; Amburgey, Jack S.; Buhrlage, Sara; Seibel, William L.; Curnow, Alan W.; Howard, Jeremy M.; Evdokimov, Artem; Pokross, Matthew. Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004 (2004),
6. Bestatin Derivatives as Potential Small-Molecule Inhibitors of Bacterial Methionine Aminopeptidase . Neil T. Fairweather, Jane F. Djung, Shari J. Soper, Jack S. Amburgey, William L. Seibel, Alan W. Curnow, Jeremy M. Howard, Artem Evdokimov, and Matthew Pokross. 39th National Organic Chemistry Symposium (A77), Salt lake City, UT, United States, June 12-16, 2005.