Genome Research Instituted
2180 E. Galbraith Rd
Cincinnati, OH 45237
Phone: 513-558-0080

Email Eric

Publications

Dr. Eric Hu was trained as a synthetic and medicinal chemist with focus on drug discovery and development. He has been involved in drug research projects of new antibacterial and anti-obesity agents. His recent contribution is the discovery of a novel quinolone antibiatics has led to the Phase-II clinical study. His other interests include design and synthesis of small molecules and peptidomimetics for biological activity.



Publications

1:

Kim N, Meyers KM, Mendez-Andino JL, Warshakoon NC, Ji W, Wos JA, Colson A, Mitchell MC, Davis JR, Pinney BB, Reizes O, Hu XE Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity. Bioorg Med Chem Lett. 2006 Oct;16(20):5445-50. PMID: 16879961 [PubMed - indexed for MEDLINE]

2:

Warshakoon NC, Sheville J, Bhatt RT, Ji W, Mendez-Andino JL, Meyers KM, Kim N, Wos JA, Mitchell C, Paris JL, Pinney BB, Reizes O, Hu XE Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents. Bioorg Med Chem Lett. 2006 Oct;16(19):5207-11. PMID: 16870427 [PubMed - indexed for MEDLINE]

3:

Tian X, Mishra RK, Switzer AG, Hu XE, Kim N, Mazur AW, Ebetino FH, Wos JA, Crossdoersen D, Pinney BB, Farmer JA, Sheldon RJ Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep;16(17):4668-73. PMID: 16766182 [PubMed - indexed for MEDLINE]

4:

Hu XE, Kim NK, Gray JL, Almstead JI, Seibel WL, Ledoussal B Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. J Med Chem. 2003 Aug;46(17):3655-61. PMID: 12904069 [PubMed - indexed for MEDLINE]

5:	Gray JL, Almstead JI, Gallagher CP, Hu XE, Kim NK, Taylor CJ, Twinem TL, Wallace CD, Ledoussal B Synthesis and biological testing of non-fluorinated analogues of levofloxacin. Bioorg Med Chem Lett. 2003 Jul;13(14):2373-5. PMID: 12824037 [PubMed - indexed for MEDLINE]

6:	Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochim Biophys Acta. 2002 Apr;1589(2):140-50. PMID: 12007789 [PubMed - indexed for MEDLINE]

7:	Nadler MJ, Hu XE, Cassady JM, Geahlen RL Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases. Biochim Biophys Acta. 1994 Jun;1213(1):100-6. PMID: 8011671 [PubMed - indexed for MEDLINE]

8:

Hu XE, Kim NK, Gray JL, Almstead JI, Seibel WL, Ledoussal B Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. J Med Chem. 2003 Aug;46(17):3655-61. PMID: 12904069 [PubMed - indexed for MEDLINE]

9:	Hu XE, Kim NK, Ledoussal B Synthesis of trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines via ring-closing metathesis reaction. Org Lett. 2002 Dec;4(25):4499-502. PMID: 12465922 [PubMed - indexed for MEDLINE]

10:	Gray JL, Almstead JI, Gallagher CP, Hu XE, Kim NK, Taylor CJ, Twinem TL, Wallace CD, Ledoussal B Synthesis and biological testing of non-fluorinated analogues of levofloxacin. Bioorg Med Chem Lett. 2003 Jul;13(14):2373-5. PMID: 12824037 [PubMed - indexed for MEDLINE]