Department of Molecular Oncogenesis
Genome Research Institute
University of Cincinnati
2180 E. Galbraith Road
Cincinnati, OH 45237
Phone: (513) 558 8420
Fax: (513) 558 5061

Email Maria

Publications

The Ras proto-oncogene is central to the control of cell growth and survival, and its oncogene form has been shown to be mutated in numerous human cancers. Previous results from our laboratory showed that inhibition of the atypical protein kinase C (aPKC) impairs Ras-induced transformation, as well as that aPKC interacts with Ras in vitro and in vivo. These observations suggested that the aPKCs could be important regulators of Ras function, and would be consistent with a model according to which Ras, through regulation of the aPKCs, which control NF-kB, would modulate tumor cell survival. Consistent with this hypothesis, we found that the proapoptotic regulator Par-4 binds and inhibits the aPKCs, which translates into a reduction in NF-kB activity and enhanced cell death. Furthermore, Ras-induced transformation leads to the downregulation of Par-4 levels and the subsequent activation of aPKC and NF-kB transcriptional activity. This suggests that Par-4 depletion is a critical event in Ras-induced transformation. In agreement with this notion, restoration by ectopic expression of Par-4 to parental levels, although does not modify the morphological characteristics of the Ras transformants, it restrains growth of these tumor cells, inhibits their ability to grow in soft agar, and reduces their tumor-forming capacity in nude mice. Moreover, Par-4-/- cells display enhanced aPKC and NF-kB activities as well as reduced apoptosis. Also, Par-4-deficient mice are prone to cancer, particularly prostate intraepithelial neoplasia, which is abrogated in Par-4/aPKC double KO cells (preliminary results), suggesting that aPKC is a bona fide Par-4 target in cancer. Collectively these results indicate that the aPKCs may be considered important intermediates in Ras-induced transformation. Our present interest is to understand the implication of the aPKCs, and in particular the aPKC isoform in the generation of prostate adenocarcinomas and hormone therapy resistance in these tumors. As the aPKCs have been implicated in the regulation of NF-kB, we will address the role and mechanism whereby this important transcription factor controls prostate cell survival and proliferation during tumor transformation.


Publications

1:	Moscat J, Diaz-Meco MT, Albert A, Campuzano S Cell signaling and function organized by PB1 domain interactions. Mol Cell. 2006 Sep;23(5):631-40. PMID: 16949360 [PubMed - indexed for MEDLINE]

2:	Martin P, Diaz-Meco MT, Moscat J The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. EMBO J. 2006 Aug;25(15):3524-33. PMID: 16874300 [PubMed - indexed for MEDLINE]

3:	Rodriguez A, Durán A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 2006 Mar;3(3):211-22. PMID: 16517408 [PubMed - indexed for MEDLINE]

4:	Moscat J, Rennert P, Diaz-Meco MT PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Cell Death Differ. 2006 May;13(5):702-11. PMID: 16322752 [PubMed - indexed for MEDLINE]

5:	Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem. 2005 Oct;280(42):35625-9. PMID: 16079148 [PubMed - indexed for MEDLINE]

6:

Martin P, Villares R, Rodriguez-Mascarenhas S, Zaballos A, Leitges M, Kovac J, Sizing I, Rennert P, Márquez G, Martínez-A C, Diaz-Meco MT, Moscat J Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A. 2005 Jul;102(28):9866-71. PMID: 15987782 [PubMed - indexed for MEDLINE]

7:	García-Cao I, Duran A, Collado M, Carrascosa MJ, Martín-Caballero J, Flores JM, Diaz-Meco MT, Moscat J, Serrano M Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep. 2005 Jun;6(6):577-83. PMID: 15877079 [PubMed - indexed for MEDLINE]

8:	Durán A, Rodriguez A, Martin P, Serrano M, Flores JM, Leitges M, Diaz-Meco MT, Moscat J Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J. 2004 Nov;23(23):4595-605. PMID: 15526032 [PubMed - indexed for MEDLINE]

9:

Sole C, Dolcet X, Segura MF, Gutierrez H, Diaz-Meco MT, Gozzelino R, Sanchis D, Bayascas JR, Gallego C, Moscat J, Davies AM, Comella JX The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. J Cell Biol. 2004 Nov;167(3):479-92. PMID: 15520226 [PubMed - indexed for MEDLINE]

10:	Sotillos S, Díaz-Meco MT, Caminero E, Moscat J, Campuzano S DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol. 2004 Aug;166(4):549-57. PMID: 15302858 [PubMed - indexed for MEDLINE]

11:	Durán A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, Diaz-Meco MT The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell. 2004 Feb;6(2):303-9. PMID: 14960283 [PubMed - indexed for MEDLINE]

12:	Lafuente MJ, Martin P, Garcia-Cao I, Diaz-Meco MT, Serrano M, Moscat J Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J. 2003 Sep;22(18):4689-98. PMID: 12970181 [PubMed - indexed for MEDLINE]

13:	Duran A, Diaz-Meco MT, Moscat J Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J. 2003 Aug;22(15):3910-8. PMID: 12881425 [PubMed - indexed for MEDLINE]

14:	Moscat J, Diaz-Meco MT Par-4 keeps the atypical PKCs at bay. Cell Cycle. ;2(2):71-2. PMID: 12695647 [PubMed - indexed for MEDLINE]

15:	Garcia-Cao I, Lafuente MJ, Criado LM, Diaz-Meco MT, Serrano M, Moscat J Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep. 2003 Mar;4(3):307-12. PMID: 12634851 [PubMed - indexed for MEDLINE]

16:	Moscat J, Diaz-Meco MT, Rennert P NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep. 2003 Jan;4(1):31-6. PMID: 12524517 [PubMed - indexed for MEDLINE]

17:	Avila A, Silverman N, Diaz-Meco MT, Moscat J The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol Cell Biol. 2002 Dec;22(24):8787-95. PMID: 12446795 [PubMed - indexed for MEDLINE]

18:	Martin P, Duran A, Minguet S, Gaspar ML, Diaz-Meco MT, Rennert P, Leitges M, Moscat J Role of zeta PKC in B-cell signaling and function. EMBO J. 2002 Aug;21(15):4049-57. PMID: 12145205 [PubMed - indexed for MEDLINE]

19:	Moscat J, Diaz-Meco MT The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies. Adv Enzyme Regul. 2002 ;42():173-9. PMID: 12123714 [PubMed - indexed for MEDLINE]

20:	Ponting CP, Ito T, Moscat J, Diaz-Meco MT, Inagaki F, Sumimoto H OPR, PC and AID: all in the PB1 family. Trends Biochem Sci. 2002 Jan;27(1):10. PMID: 11796218 [PubMed - indexed for MEDLINE]

21:	Wooten MW, Vandenplas ML, Seibenhener ML, Geetha T, Diaz-Meco MT Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol Cell Biol. 2001 Dec;21(24):8414-27. PMID: 11713277 [PubMed - indexed for MEDLINE]

22:	Leitges M, Sanz L, Martin P, Duran A, Braun U, García JF, Camacho F, Diaz-Meco MT, Rennert PD, Moscat J Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell. 2001 Oct;8(4):771-80. PMID: 11684013 [PubMed - indexed for MEDLINE]

23:	Moscat J, Sanz L, Sanchez P, Diaz-Meco MT Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation. Adv Enzyme Regul. 2001 ;41():99-120. PMID: 11384740 [PubMed - indexed for MEDLINE]

24:	Moscat J, Diaz-Meco MT The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep. 2000 Nov;1(5):399-403. PMID: 11258478 [PubMed - indexed for MEDLINE]

25:	Wooten MW, Seibenhener ML, Mamidipudi V, Diaz-Meco MT, Barker PA, Moscat J The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem. 2001 Mar;276(11):7709-12. PMID: 11244088 [PubMed - indexed for MEDLINE]

26:	Diaz-Meco MT, Moscat J MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol. 2001 Feb;21(4):1218-27. PMID: 11158308 [PubMed - indexed for MEDLINE]

27:	van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Cáceres JF The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol. 2000 Apr;149(2):307-16. PMID: 10769024 [PubMed - indexed for MEDLINE]

28:	Sanz L, Diaz-Meco MT, Nakano H, Moscat J The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000 Apr;19(7):1576-86. PMID: 10747026 [PubMed - indexed for MEDLINE]

29:	Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J. 1999 Nov;18(22):6362-9. PMID: 10562548 [PubMed - indexed for MEDLINE]

30:

Diaz-Meco MT, Lallena MJ, Monjas A, Frutos S, Moscat J Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem. 1999 Jul;274(28):19606-12. PMID: 10391896 [PubMed - indexed for MEDLINE]

31:	Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 1999 Jun;18(11):3044-53. PMID: 10356400 [PubMed - indexed for MEDLINE]

32:	Frutos S, Moscat J, Diaz-Meco MT Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis. J Biol Chem. 1999 Apr;274(16):10765-70. PMID: 10196149 [PubMed - indexed for MEDLINE]

33:	Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol. 1999 Mar;19(3):2180-8. PMID: 10022904 [PubMed - indexed for MEDLINE]

34:	Berra E, Diaz-Meco MT, Moscat J The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem. 1998 Apr;273(17):10792-7. PMID: 9553146 [PubMed - indexed for MEDLINE]

35:	Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol. 1998 May;18(5):3069-80. PMID: 9566925 [PubMed - indexed for MEDLINE]

36:	Berra E, Municio MM, Sanz L, Frutos S, Diaz-Meco MT, Moscat J Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol. 1997 Aug;17(8):4346-54. PMID: 9234692 [PubMed - indexed for MEDLINE]

37:	Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J, Rapp U, Cooper GM Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol. 1997 Feb;17(2):732-41. PMID: 9001227 [PubMed - indexed for MEDLINE]

38:	Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell. 1996 Sep;86(5):777-86. PMID: 8797824 [PubMed - indexed for MEDLINE]

39:	Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. J Biol Chem. 1996 Jul;271(30):18231-6. PMID: 8663478 [PubMed - indexed for MEDLINE]

40:

Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Mol Cell Biol. 1996 Jan;16(1):105-14. PMID: 8524286 [PubMed - indexed for MEDLINE]

41:	Folgueira L, McElhinny JA, Bren GD, MacMorran WS, Diaz-Meco MT, Moscat J, Paya CV Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. J Virol. 1996 Jan;70(1):223-31. PMID: 8523529 [PubMed - indexed for MEDLINE]

42:	Berra E, Díaz-Meco MT, Lozano J, Frutos S, Municio MM, Sánchez P, Sanz L, Moscat J Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J. 1995 Dec;14(24):6157-63. PMID: 8557035 [PubMed - indexed for MEDLINE]

43:

Martínez-Gimeno C, Díaz-Meco MT, Domínguez I, Moscat J Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Head Neck. ;17(6):516-25. PMID: 8847210 [PubMed - indexed for MEDLINE]

44:	Bjørkøy G, Overvatn A, Diaz-Meco MT, Moscat J, Johansen T Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem. 1995 Sep;270(36):21299-306. PMID: 7673165 [PubMed - indexed for MEDLINE]

45:	Municio MM, Lozano J, Sánchez P, Moscat J, Diaz-Meco MT Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta. J Biol Chem. 1995 Jun;270(26):15884-91. PMID: 7541049 [PubMed - indexed for MEDLINE]

46:	Sanz L, Moscat J, Diaz-Meco MT Molecular characterization of a novel transcription factor that controls stromelysin expression. Mol Cell Biol. 1995 Jun;15(6):3164-70. PMID: 7760812 [PubMed - indexed for MEDLINE]

47:	Diaz-Meco MT, Lozano J, Municio MM, Berra E, Frutos S, Sanz L, Moscat J Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J Biol Chem. 1994 Dec;269(50):31706-10. PMID: 7989344 [PubMed - indexed for MEDLINE]

48:	Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem. 1994 Jul;269(30):19200-2. PMID: 8034680 [PubMed - indexed for MEDLINE]

49:	Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J. 1994 Jun;13(12):2842-8. PMID: 8026469 [PubMed - indexed for MEDLINE]

50:

Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem. 1994 Apr;269(13):10044-9. PMID: 8144503 [PubMed - indexed for MEDLINE]

51:

Johansen T, Bjørkøy G, Overvatn A, Diaz-Meco MT, Traavik T, Moscat J NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Mol Cell Biol. 1994 Jan;14(1):646-54. PMID: 8264633 [PubMed - indexed for MEDLINE]

52:	Cai H, Erhardt P, Troppmair J, Diaz-Meco MT, Sithanandam G, Rapp UR, Moscat J, Cooper GM Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol. 1993 Dec;13(12):7645-51. PMID: 8246981 [PubMed - indexed for MEDLINE]

53:

Arenzana-Seisdedos F, Fernandez B, Dominguez I, Jacqué JM, Thomas D, Diaz-Meco MT, Moscat J, Virelizier JL Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol. 1993 Nov;67(11):6596-604. PMID: 8411362 [PubMed - indexed for MEDLINE]

54:	Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell. 1993 Aug;74(3):555-63. PMID: 7688666 [PubMed - indexed for MEDLINE]

55:	Diaz-Meco MT, Berra E, Municio MM, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera MT, Alcamí J, Payá CV A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol. 1993 Aug;13(8):4770-5. PMID: 8336714 [PubMed - indexed for MEDLINE]

56:	Dominguez I, Sanz L, Arenzana-Seisdedos F, Diaz-Meco MT, Virelizier JL, Moscat J Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol. 1993 Feb;13(2):1290-5. PMID: 8423794 [PubMed - indexed for MEDLINE]

57:	Cai H, Erhardt P, Szeberényi J, Diaz-Meco MT, Johansen T, Moscat J, Cooper GM Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Mol Cell Biol. 1992 Dec;12(12):5329-35. PMID: 1448068 [PubMed - indexed for MEDLINE]

58:	Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol. 1992 Sep;12(9):3776-83. PMID: 1508183 [PubMed - indexed for MEDLINE]

59:

Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Mol Cell Biol. 1992 Jan;12(1):302-8. PMID: 1309592 [PubMed - indexed for MEDLINE]

60:

Diaz-Meco MT, Quiñones S, Municio MM, Sanz L, Bernal D, Cabrero E, Saus J, Moscat J Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem. 1991 Nov;266(33):22597-602. PMID: 1718997 [PubMed - indexed for MEDLINE]

61:

Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, Cornet ME, Graziani G, Diaz-Meco MT, Johansen T, McCormick F, Moscat J Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO J. 1991 Nov;10(11):3215-20. PMID: 1655413 [PubMed - indexed for MEDLINE]

62:

García de Herreros A, Dominguez I, Diaz-Meco MT, Graziani G, Cornett ME, Guddal PH, Johansen T, Moscat J Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. J Biol Chem. 1991 Apr;266(11):6825-9. PMID: 2016297 [PubMed - indexed for MEDLINE]

63:

Diaz-Laviada I, Larrodera P, Nieto JL, Cornet ME, Diaz-Meco MT, Sanchez MJ, Guddal PH, Johansen T, Haro A, Moscat J Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. J Biol Chem. 1991 Jan;266(2):1170-6. PMID: 1845988 [PubMed - indexed for MEDLINE]

64:	Diaz-Laviada I, Larrodera P, Diaz-Meco MT, Cornet ME, Guddal PH, Johansen T, Moscat J Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. EMBO J. 1990 Dec;9(12):3907-12. PMID: 2123453 [PubMed - indexed for MEDLINE]

65:	Larrodera P, Cornet ME, Diaz-Meco MT, Lopez-Barahona M, Diaz-Laviada I, Guddal PH, Johansen T, Moscat J Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell. 1990 Jun;61(6):1113-20. PMID: 2112426 [PubMed - indexed for MEDLINE]

66:

Lopez-Barahona M, Kaplan PL, Cornet ME, Diaz-Meco MT, Larrodera P, Diaz-Laviada I, Municio AM, Moscat J Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade. J Biol Chem. 1990 Jun;265(16):9022-6. PMID: 2188971 [PubMed - indexed for MEDLINE]

67:	Moscat J, Cornet ME, Diaz-Meco MT, Larrodera P, Lopez-Alanon D, Lopez-Barahona M Activation of phosphatidylcholine-specific phospholipase C in cell growth and oncogene transformation. Biochem Soc Trans. 1989 Dec;17(6):988-91. PMID: 2560749 [PubMed - indexed for MEDLINE]

68:	Diaz-Meco MT, Larrodera P, Lopez-Barahona M, Cornet ME, Barreno PG, Moscat J Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists. Biochem J. 1989 Oct;263(1):115-20. PMID: 2557819 [PubMed - indexed for MEDLINE]