Prof. Jay R. Hove
2180 E. Galbraith Rd.
Cincinnati, OH 45237
Phone: 513-558-1090

Email Jay

Honors
Funding
Publications

The Hove laboratory utilizes both physiological and bioengineering approaches to determine the roles of biophysical forces, both within and around living systems, on both healthy and pathological form and function. We are particularly interested in the purported role of biological fluid flow as a morphogen for a variety of human diseases including cardiovascular disease, polycystic kidney disease, and obesity. These research efforts frequently require analysis across a wide-range of biological organizational, from the intact organism, to the tissues that compose the living conduits through which biofluids flow, down to the developmental gene expression program that serves to effect changes in the functional phenotype. With our colleagues, we are also developing a new suite of phenotyping tools with which to more effectively interrogate a powerful new animal model system of human disease, the zebrafish.


Honors:
2006 NIH-NCRR nominee for a Presidential Early Career Award in Science & Engineering (PECASE)
2005 PEW Scholar in Biomedical Sciences - nominee, of the University of Cincinnati
2004 Nominee, Bartholomew Award, Society for Integrative and Comparative Biology
2002 Laverna Titus Award for outstanding oral presentation, American Heart Association’s Young Investigators Forum, San Diego, CA
2002 Calgary Award in Cardiovascular Biomechanics, IV World Congress of Biomechanics, Calgary, Alberta
2000 Postdoctoral Fellowship Award from the American Heart Association
1999 UCLA Scherbaum Award for distinguished research by a graduate student, Department of Organismal Biology, Ecology & Evolution
1999 UCLA James Memorial Fellowship, Department of Organismal Biology, Ecology & Evolution
1998 UCLA Department of Biology nominee for 1999 College of Letters and Science Outstanding Graduate Student Award.
1998 UCLA Dissertation Year Fellowship
1996 UCLA Schectman Award for outstanding graduate student instruction, Department of Biology
1996 UCLA Department of Biology nominee for campus-wide Luckman Distinguished Teaching Award



Funding Support
2007 NIH-NIDDK. "Diet Composition and SPA in a Zebrafish Obesity Model."(PI)
2006 NIH-NCRR. "In vivo PIV: a platform technology for phenotyping flow in animal model systems."(PI)
2005 Kidney Foundation of Greater Cincinnati. "The role of shear stress on cyst development in the pronephric kidney."(PI)
2005 AHA/OVA. “Role of negative shear stress in the timing of heart valve formation."(PI)
2005 NIH/NIEHS. “Secondhand smoke and cardiovascular disease in zebrafish.” (Co-I)
2003 AHA/WSA. “Quantitative mapping of flow-induced forces during vertebrate cardiogenesis”.(PI)
2003 AHAF/NHF. “Inducing reversible stenoses for hemodynamic studies”.(PI)
2003 NSF/SGER. “In vivo hemodynamic mapping using DPIV”.(PI)
2003 NASA. “Mechano-chemical responses to the developing zebrafish heart to flow-induced forces in simulated microgravity”.(Co-I)
2000 AHA Postdoctoral Fellowship.
1998 Department of Biology Research Grant. UCLA
1997 Department of Biology Research Grant. UCLA
1997 Sigma Xi Grant-in-Aid of Research.
1997 American Society of Ichthyologists and Herpetologists Raney Award
1997 ONR/AASERT “Fishes as Autonomous Underwater Vehicles (AUVs).” (Graduate Student Author)
1996 ONR, Biological & Biomedical Science & Technology Division.
"Biomechanics and Energetics of Locomotion in Rigid-Bodied Fishes”. (Graduate Student Co-author)
1995 Lerner-Gray Fund for Marine Research
1995 Cen Cal/Seaviews Marine Science Scholarship


Publications

1:	Craig MP, Gilday SD, Hove JR Dose-dependent effects of chemical immobilization on the heart rate of embryonic zebrafish. Lab Anim (NY). 2006 Oct;35(9):41-7. PMID: 17008908 [PubMed - indexed for MEDLINE]

2:	Hove JR Quantifying cardiovascular flow dynamics during early development. Pediatr Res. 2006 Jul;60(1):6-13. PMID: 16690955 [PubMed - indexed for MEDLINE]

3:	Forouhar AS, Liebling M, Hickerson A, Nasiraei-Moghaddam A, Tsai HJ, Hove JR, Fraser SE, Dickinson ME, Gharib M The embryonic vertebrate heart tube is a dynamic suction pump. Science. 2006 May;312(5774):751-3. PMID: 16675702 [PubMed - indexed for MEDLINE]

4:	Hove JR In vivo biofluid dynamic imaging in the developing zebrafish. Birth Defects Res C Embryo Today. 2004 Sep;72(3):277-89. PMID: 15495183 [PubMed - indexed for MEDLINE]

5:	Forouhar AS, Hove JR, Calvert C, Flores J, Jadvar H, Gharib M Electrocardiographic characterization of embryonic zebrafish. Conf Proc IEEE Eng Med Biol Soc. 2004 ;5():3615-7. PMID: 17271074 [PubMed - indexed for MEDLINE]

6:	Hove JR, Köster RW, Forouhar AS, Acevedo-Bolton G, Fraser SE, Gharib M Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature. 2003 Jan;421(6919):172-7. PMID: 12520305 [PubMed - indexed for MEDLINE]

7:	Bartol IK, Gharib M, Weihs D, Webb PW, Hove JR, Gordon MS Hydrodynamic stability of swimming in ostraciid fishes: role of the carapace in the smooth trunkfish Lactophrys triqueter (Teleostei: Ostraciidae). J Exp Biol. 2003 Feb;206(Pt 4):725-44. PMID: 12517990 [PubMed - indexed for MEDLINE]

8:	Hove JR, O'Bryan LM, Gordon MS, Webb PW, Weihs D Boxfishes (Teleostei: Ostraciidae) as a model system for fishes swimming with many fins: kinematics. J Exp Biol. 2001 Apr;204(Pt 8):1459-71. PMID: 11273807 [PubMed - indexed for MEDLINE]

9:	Gordon MS, Hove JR, Webb PW, Weihs D Boxfishes as unusually well-controlled autonomous underwater vehicles. Physiol Biochem Zool. ;73(6):663-71. PMID: 11121341 [PubMed - indexed for MEDLINE]