Room 285, Bld D
GRI, UC
2180 E Galbraith road
45237 Cincinnati
Ph: 513-558-8113

Email Anand

Publications

I am from Chennai, India. After my PhD at the Institute of Molecular Biology, University of Zurich under the supervison of Prof. Walter Schaffner, I joined the lab of Prof. George Thomas as a postdoc in 2004. I use Drosophila melanogaster as a model system to understand the regulation and functions of TOR/S6K pathway. TOR/S6K pathway is implicated in a number of human pathologies including obesity, type 2 diabetes and cancer. Currently I am involved in projects related to regulation of S6 phosphorylation and its functions.
(updated Sep 2009)


Publications

1:	Dann SG, Selvaraj A, Thomas G mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med. 2007 Apr; PMID: 17452018 [PubMed - indexed for MEDLINE]

2:

Yepiskoposyan H, Egli D, Fergestad T, Selvaraj A, Treiber C, Multhaup G, Georgiev O, Schaffner W Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic Acids Res. 2006 ;34(17):4866-77. PMID: 16973896 [PubMed - indexed for MEDLINE]

3:

Egli D, Domènech J, Selvaraj A, Balamurugan K, Hua H, Capdevila M, Georgiev O, Schaffner W, Atrian S The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Genes Cells. 2006 Jun;11(6):647-58. PMID: 16716195 [PubMed - indexed for MEDLINE]

4:

Egli D, Yepiskoposyan H, Selvaraj A, Balamurugan K, Rajaram R, Simons A, Multhaup G, Mettler S, Vardanyan A, Georgiev O, Schaffner W A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Mol Cell Biol. 2006 Mar;26(6):2286-96. PMID: 16508004 [PubMed - indexed for MEDLINE]

5:

Selvaraj A, Balamurugan K, Yepiskoposyan H, Zhou H, Egli D, Georgiev O, Thiele DJ, Schaffner W Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes Dev. 2005 Apr;19(8):891-6. PMID: 15833915 [PubMed - indexed for MEDLINE]

6:	Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. Biol Chem. 2004 Jul;385(7):597-603. PMID: 15318808 [PubMed - indexed for MEDLINE]

7:

Egli D, Selvaraj A, Yepiskoposyan H, Zhang B, Hafen E, Georgiev O, Schaffner W Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. EMBO J. 2003 Jan;22(1):100-8. PMID: 12505988 [PubMed - indexed for MEDLINE]